Internucleosomal chromatin degradation in myeloma and B-hybridoma cell cultures
نویسندگان
چکیده
منابع مشابه
On chip electrofusion of single human B cells and mouse myeloma cells for efficient hybridoma generation.
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Native chromosomal structure, breakage, and overall degradation were studied following the reaction of whole cells with the anticancer drug bleomycin and structurally related phleomycin. Electrophoretic analyses of cellular DNA established that phleomycin was more reactive with DNA than equimolar bleomycin in the range of 0.67-33 x 10(-6) M, produced an optimally visible, though less-extended, ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1992
ISSN: 0014-5793
DOI: 10.1016/0014-5793(92)81213-6